The incidence of pressure injuries in the hospital is one of the unexpected events during hospitalization in the context of patient safety (Slawomirski et al., 2020). Pressure ulcers affect the social, mental, and physical well-being of patients; increase treatment costs; prolong hospital stays; increase patient risk for infections; and may independently decrease life expectancy. A study by Manzano et al., (2014) identified pressure injury as a significant independent predictor of mortality in mechanically ventilated patients. Ventilator-associated pneumonia (VAP) is one of the main causes of morbidity and mortality in the hospitals, despite improved antimicrobial therapy, supportive care, and prevention (). Ventilator-associated pneumonia adds significant costs to individual hospitalizations. The mortality rate attributable to VAP is 27% and has been as high as 43% when the causative agent was antibiotic resistant, and it is associated with increases in morbidity and mortality, hospital length of stay, and costs (). Studies show that apart from the extra costs to treat VAP, extended hospital stay, and extra surgical procedures and working hours, there are also litigation factors that the hospitals face from the patients and families. Suggested practice changes or interventions to address the issues. A study by Boltey, Yakusheva, & Costa, (2017) states that nurses can lead the commitment to reducing VAP and improving quality of care for mechanically ventilated patients by coordinating and implementing these evidence-based practices. One of the Essentials of the Doctoral Education for Advanced Nursing Practice is the Clinical Prevention and Population Health for Improving the Nation’s Health. DNP graduates engage in leadership to integrate and institutionalize evidence-based clinical prevention and population health services for individuals,